The specimens of four large cohort studies, whose samples are housed at the BWH/Harvard Cohorts Biorespository, provide rich data for researchers, including DNA samples that have been genotyped. But the different genome-wide association studies (GWAS) used across the studies made it a challenge to analyze secondary phenotypes or share controls across the studies. To allow for secondary analyses, researchers created a pooled resource of new datasets and describe the methodology behind it.
Lindström S, Loomis S, Turman C, Huang H, Huang J, Aschard H, et al. (2017) A comprehensive survey of genetic variation in 20,691 subjects from four large cohorts. PLoS ONE 12(3): e0173997. https://doi.org/10.1371/journal.pone.0173997
Full text: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0173997